Recent Publications

2007

Shengping Qin, Dustin E. Kruse, Katherine W. Ferrara, "Transmitted Ultrasound Pressure Variation In Micro Blood Vessel Phantoms", Ultrasound in Med. & Biol., Vol. 34, No. x, pp. xxx, 2008

Driving delivery vehicles with ultrasound, Katherine W. Ferrara, Advanced Drug Delivery Reviews (2008), doi: 10.1016/j.addr.2008.03.002

Imaging of angiogenesis using CadenceTM contrast pulse sequencing and targeted contrast agents Susanne M. Stieger, Paul A. Dayton, Mark A. Borden, Charles F. Caskey, Stephen M. Griffey, Erik R. Wisner and Katherine W. Ferrara,* Contrast Media Mol. Imaging 2008 , 3 9–18.

H Zhang, J Kusnose, A Kheirolomoom, J Qi, E Ruoslahti, J Sutcliffe, KW Ferrara "Dynamic Imaging to of Cardiac Vasculature with Arginine-rich Peptide-targeted Vehicles in a Mouse Model," Biomaterials, Epub Feb. 6, 2008, doi:10.1016/j.biomaterials.2007.12.033.

Borden MA, Zhang H, Gillies RJ, Dayton PA, Ferrara KW, "A stimulus-responsive contrast agent for ultrasound molecular imaging," Biomaterials, 2008 Feb;29(5):597-606. Epub 2007 Oct 30.

Mark A. Borden, Charles Caskey, Erica Little, Robert J. Gillies & Katherine W. Ferrara, "DNA and polylysine adsorption and multilayer construction onto cationic lipid-coated microbubbles",. Langmuir, epub August 3, 2007.

Charles Caskey, Susanne Stieger, Shengping Qin, Paul Dayton, Katherine W. Ferrara, “Direct observation of microbubble interaction with the endothelium,” Journal of the Acoustical Society of America, 122(2) August, 2007, 1191-1200.

Katherine Ferrara, Rachel Pollard, Mark Borden, "Ultrasound Microbubble Contrast Agents: Fundamentals and Application to Gene and Drug Delivery", Annual Review of Biomedical Engineering, Vol. 9: 415-447 (Volume publication date August 2007)

Azadeh Kheirolomoom, Katherine W. Ferrara, “Cholesterol transport from liposomal delivery vehicles,”Biomaterials, Jun 5, 2007.

Shengping Qin, Katherine W. Ferrara, “The natural frequency of nonlinear oscillation of ultrasound contrast agents in microvessels,” Ultrasound in Medicine and Biology, Epub ahead of print, May 1, 2007.

Susanne M. Stieger, Charles F. Caskey, S. Qin, Roger H. Adamson, Fitz-Roy E. Curry, Erik R. Wisner, Katherine W. Ferrara, "Enhancement of vascular permeability with low frequency contrast ultrasound," Radiology, 2007 April, 243(1), 112-121.

Shukui Zhao, Dustin E. Kruse, Katherine W. Ferrara, and Paul A. Dayton, "Detection of adherent ultrasound contrast agents," Physics in Medicine and Biology, 52 (2007), 2055-2072.

Yang Sun, Dustin E. Kruse, Katherine W. Ferrara, "Contrast imaging with chirped excitation," IEEE Transactions on UFFC, March 2007, 54(3), 520-529.

Azadeh Kheirolomoom, Paul A. Dayton, Aaron F.H. Lum, Katherine W. Ferrara, "Characterization of a New Acoustically-Active Drug Delivery Vehicle Based on Liposomes Conjugated to Microbubbles," Journal of Controlled Release, 2006 Dec 23; [Epub ahead of print].

Jan Marik, Michaelann J. Shortencarier, Julie L. Sutcliffe-Goulden, Katherine W. Ferrara, "Long-circulating liposomes radiolabeled with [18F]fluorodipalmitin ([18F]FDP)," Nuclear Medicine in Biology, 2007 Feb;34(2):165-171.

Pollard RE, Broumas AR, Wisner ER, Vekich SV, Ferrara KW, "Quantitative contrast enhanced ultrasound and ct assessment of tumor response to antiangiogenic therapy in rats," Available online 16 December 2006, Ultrasound in Medicine & Biology 2007 Feb;33(2):235-245.

2006

Michaelann Shortencarier Tartis, Jennifer McCallan, Aaron F.H. Lum, Rachel LaBell, Susanne M. Stieger, Terry O. Matsunaga and Katherine W. Ferrara, "Therapeutic effects of paclitaxel-containing ultrasound contrast agents," Ultrasound in Medicine & Biology, Volume 32, Issue 11, November 2006, Pages 1771-1780.

Shukui Zhao, Dustin E. Kruse, Katherine W. Ferrara, and Paul A. Dayton, "Acoustic response from adherent targeted contrast agents", Jasa Electronic Letters, 120(6), Dec. 2006, Epublished Oct. 2006, pp. EL63-EL69

Shengping Qin and Katherine W Ferrara, "Acoustic response of compliable microvessels containing ultrasound contrast agents", Phys. Med. Biol. 51 (2006) 5065-5088, September, 2006

Paul Dayton, Shukui Zhao, Susannah Bloch, Patricia A Schumann, Kim Penrose, Terry O Matsunaga, Reena Zutshi, Alexander Doinikov and Katherine W Ferrara, "Application of ultrasound to selectively localize nanodroplets for targeted imaging and therapy", Molecular Imaging, 5(3), July 2006

Mark A Borden, Melissa R Sarantos, Susanne M Stieger, Scott I Simon, Katherine W Ferrara and Paul Dayton, "Ultrasound Radiation Force Modulates Ligand Availability on Targeted Contrast Agents", Molecular Imaging, 5(3), July 2006

R. Pollard, R. Yunis, D. Kueltz, P. Martin, S. Griffey, K. Ferrara, "Ultrasonic detection and characterization of polycystic kidney disease in a mouse model," Comparative Medicine, 2006 Jun; 56(3):215-21

Yang Sun, Shukui Zhao, Paul A. Dayton and Katherine W. Ferrara, "Observation of contrast agent response to chirp insonation with a simultaneous optical-acoustical system," IEEE Transactions on UFFC, June 2006, 53(6), 1130-1137

Stieger SM, Bloch SH, Foreman O, Wisner ER, Ferrara KW, Dayton P, "Ultrasound assessment of angiogenesis in a Matrigel model in rats," Ultrasound in Medicine and Biology, May 2006, 32(5):673-81

A. Louie, J. Izatt, Katherine Ferrara, "Biomedical Imaging Graduate Curricula and Courses: Report from the 2005 Whitaker Biomedical Engineering Educational Summit," Annals of Biomedical Engineering, Ann Biomed Eng. 2006 Feb;34(2):239-47. Epub 2006 Feb 16.

Mark A. Borden, Josette Ricker, Nelly Tsvetkova, Marjorie Longo, Paul A.Dayton & Katherine W. Ferrara, "Lateral phase separation in lipid-monolayer coated microbubbles, Langmuir, 2006 Apr 25;22(9):4291-4297.

Charles F. Caskey, Dustin E. Kruse, Paul A. Dayton, Tyler K. Kitano, Katherine W. Ferrara. “Microbubble Oscillation in Tubes with Diameters of 12, 25, and 195 Microns,” Applied Physics Letters 88, 033902, Epub ahead of print, 2006.

2005

Aaron F H Lum, Mark A Borden, Paul A Dayton, Dustin E Kruse, Scott I Simon, Katherine W Ferrara, “Ultrasound Radiation Force Enables Targeted Deposition of Model Drug Carriers Loaded on Microbubbles,” Journal of Controlled Release, Epub ahead of print, 2005.

Shukui Zhao, Katherine W. Ferrara, and Paul A. Dayton, " Asymmetric oscillation of adherent targeted ultrasound contrast agents," Applied Physics Letters 87, 134103-1-3, (2005).

Mark A. Borden; Paul A. Dayton; Katherine W. Ferrara; " Physicochemical Properties of the Microbubble Lipid Shell ," IEEE Transactions on UFFC 25(11), November 2005, 1992-2002.

Y. Sun, D. Kruse, P. Dayton, K. Ferrara, " High-Frequency Dynamics of Ultrasound Contrast Agents ," IEEE Transactions on UFFC 25(11), November 2005, 1981-91.

Dustin Kruse, K. Ferrara, " A New Imaging Strategy Utilizing Wideband Transient Response of Ultrasound Contrast Agents ," IEEE Transactions on UFFC 52(8), August 2005, 1320-9.

S. H. Bloch, R. E. Short, K. W. Ferrara, E. R. Wisner, " The effect of size on the acoustic response of polymer shelled contrast agents ," Ultrasound in Medicine and Biology 31(3): 439-44, 2005.

Amy R. Broumas, Rachel E. Pollard, Susannah H. Bloch, Erik R. Wisner, Steven Griffey, and Katherine W. Ferrara, " Contrast-enhanced computed tomography and ultrasound for the evaluation of tumor blood flow ," Investigative Radiology 40(3): 134-147, 2005.

Y.T. Hu, Shengping Qin, Ting Hu, Katherine W. Ferrara, Qing Jiang, " Asymmetric oscillation of cavitation bubbles in a microvessal and its implications upon mechanisms of clinical vessel injury in shock-wave lithotripsy ." International Journal of Non-Linear Mechanics 40(2-3): 341-350, 2005.

2004

S. H. Bloch, P. A. Dayton, and K. W. Ferrara,  "Targeted imaging using ultrasound contrast agents ," IEEE Engineering in Medicine and Biology Magazine 23(5): 18-29, 2004.

S. H. Bloch, M. Wan, P. A. Dayton, and K. W. Ferrara, " Optical observation of lipid- and polymer-shelled ultrasound microbubble contrast agents ," Applied Physics Letters 84(4):631-3, 2004.

P. A. Dayton, D. P. Pearson, J. Clark, S. I. Simon, P. Schumann, R. Zutshi, T. O. Matsunaga, and K. W. Ferrara, "Ultrasonic analysis of peptide- and antibody-targeted microbubble contrast agents for molecular imaging of alpha-v beta-3 expressing cells," Molecular Imaging 3(2): 125-134, 2004.

D. N. Patel, S. H. Bloch, P. A. Dayton, and K. W. Ferrara, " Acoustic signatures of submicron contrast agents ," IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control 51(3):293-301, 2004.

R. E. Pollard, T. C. Garcia, S. M. Stieger, K. W. Ferrara, A. R. Sadlowski, and E. R. Wisner, " Quantitative evaluation of peripheral tumor perfusion and permeability using contrast enhanced computed tomography ," Investigative Radiology 39(6):340-9, 2004.

M. J. Shortencarier, P. A. Dayton, S. H. Bloch, P. A. Schumann, T. O. Matsunaga, and K. W. Ferrara, " "A method for ultrasound-localized drug delivery using gas-filled lipospheres ," IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control 51(7): 822-31, 2004.

Chih-Kuang Yeh, Katherine W. Ferrara, and Dustin E. Kruse, "High resolution functional vascular assessment with ultrasound ," IEEE Transactions on Medical Imaging 23(10): 1263-75, 2004.

S. Zhao, M. Borden, S. H. Bloch, D. Kruse, K. W. Ferrara, and P. A. Dayton, "Radiation force assisted targeting facilitates ultrasonic molecular imaging ," Molecular Imaging 3(3):135-148, 2004.

2003

J. S. Allen, D. E. Kruse, P. A. Dayton, and K. W. Ferrara, " Effect of coupled oscillations on microbubble behavior ," Journal of the Acoustical Society of America 114(3):1678-90, 2003.

J. E. Chomas, R. E. Pollard, A. R. Sadlowski, S. M. Griffey, E. R. Wisner, and K. W. Ferrara, " Contrast-enhanced US of microcirculation of superficially implanted tumors in rats ," Radiology 229(2):439-46, 2003.

E. R. Wisner, K. W. Ferrara, R. E. Short, T. B. Ottoboni, J. D. Gabe, and D. Patel, " Sentinel node detection using contrast-enhanced power Doppler ultrasound lymphography ," Investigative Radiology 38(6):358-365, 2003.

2002

J. S. Allen, D. J. May, and K. W. Ferrara, " Dynamics of therapeutic ultrasound contrast agents ," Ultrasound in Medicine and Biology 28(6):805-16, 2002.

J. Chomas, P. Dayton, D. May, and K. Ferrara, " Nondestructive subharmonic imaging ," IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control 49(7):883-92, 2002.

P. A. Dayton, J. S. Allen, and K. W. Ferrara, " The magnitude of radiation force on ultrasound contrast agents ," Journal of the Acoustical Society of America 112(5 Pt 1):2183-92, 2002.

P. A. Dayton and K. W. Ferrara, " Targeted imaging using ultrasound ," Journal of Magnetic Resonance Imaging 16(4):362-77, 2002.

D. E. Kruse and K. W. Ferrara, " A new high resolution color flow system using an eigendecomposition-based adaptive filter for clutter rejection ," IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control 49(12):1739-54, 2002.

D. J. May, J. S. Allen, and K. W. Ferrara, " Dynamics and fragmentation of thick-shelled microbubbles ," IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control 49(10):1400-10, 2002.

D. Patel, P. Dayton, J. Gut, E. Wisner, and K. W. Ferrara, " Optical and acoustical interrogation of submicron contrast agents ," IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control 49(12):1641-51, 2002.

R. E. Pollard, A. R. Sadlowski, S. H. Bloch, L. Murray, E. R. Wisner, S. Griffey, and K. W. Ferrara, " Contrast-assisted destruction-replenishment ultrasound for the assessment of tumor microvasculature in a rat model ," Technology in Cancer Research and Treatment 1(6):459-70, 2002.

R. H. Silverman, R. Ursea, D. Kruse, K. W. Ferrara, M. J. Rondeau, and D. J. Coleman, " Ultrasound measurement of the effect of temperature on microperfusion in the eye ," Ultrasound in Medicine and Biology 28(11-12):1413-9, 2002.

E. R. Wisner, K. Ferrara, J. D. Gabe, D. Patel, T. G. Nyland, R. E. Short, and T. B. Ottoboni, " Contrast enhanced intermittent power Doppler ultrasound with sub-micron bubbles for sentinel node detection ," Academic Radiology 9(Suppl 2):S389-91, 2002.

2001

J. S. Allen, D. E. Kruse, and K. W. Ferrara, " Shell waves and acoustic scattering from ultrasound contrast agents ," IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control 48(2):409-18, 2001.

J. E. Chomas, P. Dayton, J. Allen, K. Morgan, and K. W. Ferrara, " Mechanisms of contrast agent destruction ," IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control 48(1):232-48, 2001.

J. E. Chomas, P. Dayton, D. May, and K. Ferrara, " Threshold of fragmentation for ultrasonic contrast agents ," Journal of Biomedical Optics 6(2):141-50, 2001.

P. A. Dayton, J. E. Chomas, A. F. Lum, J. S. Allen, J. R. Lindner, S. I. Simon, and K. W. Ferrara, " Optical and acoustical dynamics of microbubble contrast agents inside neutrophils ," Biophysical Journa l 80(3):1547-56, 2001.

2000

J. E. Chomas, P. A. Dayton, D. May, J. Allen, A. Klibanov, and K. Ferrara, " Optical observation of contrast agent destruction ," Applied Physics Letters 77(7):1056-8, 2000.

K. W. Ferrara, C. R. Merritt, P. N. Burns, F. S. Foster, R. F. Mattrey, and S. A. Wickline, " Evaluation of tumor angiogenesis with US: imaging, Doppler, and contrast agents ," Academic Radiology 7(10):824-39, 2000.

D. Kruse and K. Ferrara, " Color flow mapping ," Ultrasound in Medicine and Biology 26(Suppl 1):S16-8, 2000.

J. R. Lindner, P. A. Dayton, M. P. Coggins, K. Ley, J. Song, K. Ferrara, and S. Kaul, " Noninvasive imaging of inflammation by ultrasound detection of phagocytosed microbubbles ," Circulation 102(5):531-8, 2000.

K. E. Morgan, J. S. Allen, P. A. Dayton, J. E. Chomas, A. L. Klibaov, and K. W. Ferrara, " Experimental and theoretical evaluation of microbubble behavior: effect of transmitted phase and bubble size ," IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control 47(6):1494-509, 2000.

1999

P. Dayton, A. Klibanov, G. Brandenburger, and K. Ferrara, " Acoustic radiation force in vivo: a mechanism to assist targeting of microbubbles ," Ultrasound in Medicine and Biology 25(8):1195-201, 1999.

P. A. Dayton, K. E. Morgan, A. L. Klibanov, G. H. Brandenburger, and K. W. Ferrara, " Optical and acoustical observations of the effects of ultrasound on contrast agents ," IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control 46(1):220-32, 1999.

R. H. Silverman, D. E. Kruse, D. J. Coleman, and K. W. Ferrara, " High-resolution ultrasonic imaging of blood flow in the anterior segment of the eye ," Investigative Opthalmology & Visual Science 40(7):1373-81, 1999.

1998

A. L. Klibanov, K. W. Ferrara, M. S. Hughes, J. H. Wible, Jr., J. K. Wojdyla, P. A. Dayton, K. E. Morgan, and G. H. Brandenburger, " Direct video-microscopic observation of the dynamic effects of medical ultrasound on ultrasound contrast microspheres ," Investigative Radiology 33(12):863-70, 1998. ( Microsoft Word , HTML )

D. E. Kruse, R. H. Silverman, R. J. Fornaris, D. J. Coleman, and K. W. Ferrara, " A swept-scanning mode for estimation of blood velocity in the microvasculature ," IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control 45(6):1437-40, 1998.

K. E. Morgan, M. Averkiou, and K. Ferrara, " The effect of the phase of transmission on contrast agent echoes ," IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control 45(4):872-5, 1998.

K. E. Morgan, P. A. Dayton, D. E. Kruse, A. L. Klibanov, G. H. Brandenburger, and K. W. Ferrara, " Changes in the echoes from ultrasonic contrast agents with imaging parameters ," IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control 45(6):1537-48, 1998.

B. G. Zagar, R. J. Fornaris, and K. W. Ferrara, " Ultrasonic mapping of the microvasculature: signal alignment ," Ultrasound in Medicine and Biology 24(6):809-24, 1998.

1997

P. A. Dayton, K. E. Morgan, A. L. Klibanov, G. Brandenburger, K. R. Nightingale, and K. W. Ferrara, " A preliminary evaluation of the effects of primary and secondary radiation forces on acoustic contrast agents ," IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control 44(6):1264-77, 1997.

A. I. el-Fallah, M. B. Plantec, and K. W. Ferrara, " Ultrasonic measurement of breast tissue motion and the implications for velocity estimation ," Ultrasound in Medicine and Biology 23(7):1047-57, 1997.

K. Ferrara and G. DeAngelis, " Color flow mapping ," Ultrasound in Medicine and Biology 23(3):321-45, 1997.

pre-1997

K. W. Ferrara, B. Zagar, J. Sokil-Melgar, and V. R. Algazi, " High resolution 3D color flow mapping: applied to the assessment of breast vasculature ," Ultrasound in Medicine and Biology 22(3):293-304, 1996.

K. W. Ferrara, B. G. Zager, J. B. Sokil-Melgar, R. H. Silverman, and I. M. Aslanidis, " Estimation of blood velocity with high frequency ultrasound ," IEEE Transactions on Ultrasonics Ferroelectrics & Frequency Control 43(1):149-57, 1996.

K. W. Ferrara, M. Ostromogilsky, S. Rosenberg, and J. Sokil-Melgar, " Parameter mapping for the detection of disturbed blood flow ," Ultrasound in Medicine and Biology 21(4):517-25, 1995.