New Journal of Clinical Investigation paper delineates curative protocols combining ablation and drug delivery (1/16).
Wong AW, Fite BZ, Liu Y, Kheirolomoom A, Seo JW, Watson KD, Mahakian LM, Tam S, Zhang H, Foiret J, Borowsky AD, Ferrara KW, Ultrasound Ablation Enhances Drug Accumulation and Survival in Mammary Carcinoma, Journal of Clinical Investigation.
Journal of Controlled Release paper demonstrates the opportunity to combine ultrasound with immune adjuvants to enhance survival (12/15)
Kheirolomoom A, Ingham ES, Mahakian LM, Tam SM, Silvestrini MT, Tumbale SK, Foiret JL, Hubbard NE, Borowsky AD, Murphy WJ, Ferrara KW, CpG Expedites Regression of Local and Systemic Tumors when Combined with Activatable Nanodelivery.
Journal of Controlled Release paper describes preferential 20-nm nanoparticle accumulation in glioblastoma (12/15)
The paper “Self-assembled 20-nm 64Cu-micelles enhance accumulation in rat glioblastoma” by Jai Woong Seo, JooChuan Ang, Lisa M. Mahakian, Sarah Tam, Brett Fite, Elizabeth S. Ingham, Janine Beyer, John Forsayeth, Krystof S. Bankiewicz, Ting Xu and Katherine W. Ferrara demonstrates the opportunity to enhance delivery to glioblastoma using small, stable micelles.
PLoS ONE paper explores MR pulse sequences combining MR-ARFI and shear wave imaging (9/24/2015)
Concurrent Visualization of Acoustic Radiation Force Displacement and Shear Wave Propagation with 7T MRI by Yu Liu, Brett Z. Fite, Lisa M. Mahakian, Sarah M. Johnson, Benoit Larrat, Erik Dumont and Katherine W. Ferrara explores sensitive scheme to determine the location of the ultrasound focus within the MRI volume.
ACS Nano paper explores anti-miRNA delivery (9/2/2015)
A collaboration between the Ferrara laboratory at UC Davis and the Jo laboratory at Emory University has resulted in a paper (Kheirolomoom A, Kim CW, Seo JW, Kumar S, Son DJ, Gagnon MK, Ingham ES, Ferrara KW, Jo H. Multifunctional Nanoparticles Facilitate Molecular Targeting and miRNA Delivery to Inhibit Atherosclerosis in ApoE-/- Mice. ACS Nano. 2015 Sep 2) demonstrating the design of nanoparticles for anti-miR delivery and the use of such particles to prevent the development of atherosclerosis.
PLoS ONE paper explores spatial and temporal control of hyperthermia (8/5/2015)
Recent paper by Josquin Foiret of the Ferrara lab (Foiret J, Ferrara KW. Spatial and Temporal Control of Hyperthermia Using Real Time Ultrasonic Thermal Strain Imaging with Motion Compensation, Phantom Study. PLoS One. 2015 Aug 5;10(8):e0134938) demonstrates the performance of real-time thermometry in the presence of tissue motion.